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Br-PBTC
产品别名
1839519-57-1
Br-PBTC
7-Bromo-N-(3R)-3-piperidinylbenzo[b]thiophene-2-carboxamide
(R)-7-Bromo-N-(piperidin-3-yl)benzo[b]thiophene-2-carboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H15BrN2OS |
| Molecular weight | 339.25 |
| Biochem/physiol Actions【生化/生理作用】 | Br-PBTC is a selective and potent type II positive allosteric modulator (PAM) that potentiates the opening of the nicotinic acetylcholine receptors (nAChR) subtypes containing α4β2, α2β2 and α2β4 subunits. Br-PBTC potentiates opening and reactivates desensitized (α4β2)2α4 nAChRs. It appears that Br-PBTC interacts with extracellular C-terminus of α2 or α4 in association with nearby parts of the α subunit. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC(C=CC=C2Br)=C2S1)N[C@@H]3CCCNC3 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
