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Cyclophilin D human
| 产品编号： | 4117667 |
| 规格： | recombinant, expressed in E. coli, ≥95% (SDS-PAGE) |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Cyclophilin D human
Peptidyl prolyl isomerase D
CYP-40
PPID
CYPD
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family. It is a mitochondrial matrix protein and a component of the mitochondrial permeability transition pore (MPTP). |
| Application【应用】 | Human cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats. |
| Biochem/physiol Actions【生化/生理作用】 | Cyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells. |
| Physical form【外形】 | 1 mg/mL solution in PBS (pH 7.4) containing 10% glycerol. |
| Preparation Note【制备说明】 | Centrifuge the vial prior to opening. |
| Other Notes【其他说明】 | MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | 42.9 kDa |
| packaging【包装】 | pkg of 100 μg |
| NCBI accession no.【NCBI登记号】 | Q08752 |
| UniProt accession no.【UniProt登记号】 | Q08752 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PPID(5481) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
