LYN A, active, GST tagged human

NA.32

LYN A is a member of the Src-family of protein kinases that participate in signaling pathways of a variety of cell surface receptors and are localized to the cytoplasmic side of the plasma membrane. LYN A is biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway. The trafficking of LYN A from the Golgi apparatus to the plasma membrane is inhibited by deletion of the kinase domain but not by kinase inactivation. The kinase domain of LYN A plays a role in LYN A trafficking besides catalysis of substrate phosphorylation. cDNA microarray analysis revealed that LYN A may be involved in the changes that are related to tumor pathogenesis.

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

expressed in baculovirus infected Sf9 cells

PRECISIO^®

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

434-657 nmol/min·mg

~81 kDa

NM_002350

dry ice

−70℃

human ... LYN(4067)

10 - Combustible liquids

WGK 1