Autophagy Inducer, STF-62247-CAS 315702-99-9-Calbiochem

C₁₅H₁₃N₃S

267.35

MFCD01121974

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC₅₀ = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.

Toxicity: Toxic (F)

Turcotte, S., et al. 2008. Cancer Cell14, 90.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

beige

DMSO: 50 mg/mL

ambient

2-8℃

10 mg in Plastic ampoule
Packaged under inert gas

H413

P273 - P501

Aquatic Chronic 4

11 - Combustible Solids

WGK 2